PDB Entry - 5U6I

(Status - Released)

Summary information:

Title: Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity

PDB DOI: https://doi.org/10.2210/pdb5u6i/pdb

Primary publication DOI: https://doi.org/10.1021/acs.jmedchem.7b00045

Entry authors: Scott, J.D., DeMong, D.E., Fell, M.J., Mirescu, C., Basu, K., Greshock, T.J., Morrow, J.A., Xiao, L., Hruza, A., Harris, J., Tiscia, H.E., Chang, R.K., Embrey, M.W., McCauley, J.A., Li, W., Lin, S., Liu, H., Dai, X., Baptista, M., Agnihotri, G., Columbus, J., Mei, H., Poirier, M., Zhou, X., Lin, Y., Yin, Z., Sanders, J.M., Drolet, R.E., Kern, J.T., Kennedy, M.E., Parker, E.M., Stamford, A.W., Nargund, R., Miller, M.W.

Initial deposition on: 8 December 2016

Initial release on: 15 March 2017

Latest revision on: 4 October 2023

Downloads:

Structure coordinates (PDBx/mmCIF)

Structure coordinates (PDBML)

Structure coordinates (PDB)

X-ray diffraction data (PDBx/mmCIF)

Validation report (XML)

Validation report (PDF)

Validation report (mmCIF)

Links to more resources for 5U6I at: