PDB Entry - 9OOI (pdb_00009ooi)

(Status - Released)

Summary information:

Title: Crystal structure of dihydrofolate reductase (DHFR) from the filarial nematode W. bancrofti in complex with NADPH and antifolate 2-({4-[(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzoic acid (OG7 or TSD001)

PDB DOI: https://doi.org/10.2210/pdb9ooi/pdb

Primary publication DOI: https://doi.org/10.1016/j.bmcl.2025.130370

Entry authors: Frey, K.M., Goodey, N.M., Kwarteng, S.

Initial deposition on: 15 May 2025

Initial release on: 27 August 2025

Latest revision on: 27 August 2025

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Structure coordinates (PDBx/mmCIF)

Structure coordinates (PDB)

Structure coordinates (PDBML)

X-ray diffraction data (PDBx/mmCIF)

Validation report (XML)

Validation report (PDF)

Validation report (mmCIF)

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